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Endometriosis Flare-Ups: Symptoms and Management

June Lawver
June Lawver · December 16, 2024
3 min read · Sources Verified
Medical review by Kat McGraw MD
How, when, and why endometriosis flare-ups occur.

Endometriosis is a common yet complex condition that affects approximately 1 in 10 women of reproductive age, making it the second most prevalent gynecological disorder after polycystic ovary syndrome (PCOS). While many associate endometriosis with painful periods, its symptoms can extend far beyond painful menstruation, particularly during flare-ups. These episodes of heightened discomfort are tied to hormonal changes and can significantly impact quality of life for some. This article explores the causes, timing, symptoms, and management strategies for endometriosis flare-ups.

What Is Endometriosis?

Endometriosis occurs when tissue similar to the lining of the uterus, known as endometrial-like tissue, grows outside the uterus. This excess tissue can attach to various organs and surfaces, such as the ovaries, pelvic walls, or bladder. Unlike normal endometrial tissue, which sheds during menstruation, this misplaced tissue has no outlet, leading to inflammation, scar tissue, and pain.

Infographic explaining how endometriosis flare-ups occur
Why Endometriosis Flare-Ups Occur

Key symptoms of endometriosis include:

Endometriosis is distinct from adenomyosis, in which endometrial tissue grows in the muscular wall of the uterus, aka the myometrium. Both can cause severe pain, but they’re different conditions with unique challenges and treatment strategies.

How Do Endometriosis Flare-Ups Work?

Flare-ups in endometriosis are periods when symptoms intensify, often triggered by hormonal fluctuations like spikes in estrogen.

Estrogen, a key hormone involved in regulating the menstrual cycle, fuels the growth of endometrial tissue. In individuals with endometriosis, excess or unbalanced estrogen can exacerbate the condition, especially during cycle phases when estrogen is naturally higher.

Compounding the problem, endometriosis tissue may become resistant to progesterone—a hormone that typically counteracts estrogen's effects. This resistance creates a domino effect, exacerbating already severe symptoms.

When Do Flare-Ups Occur?

Endometriosis symptoms can manifest at any point in the menstrual cycle, but flare-ups can be more common during menstruation and before ovulation, which is when estrogen levels are high.

Graph showing when endometriosis flare-ups are likely to occur during the menstrual cycle.
Endometriosis flare-ups are more likely to occur during menstruation and around ovulation

Before and During Menstruation: During your period, the endometrial tissue inside the uterus is shed. In endometriosis, the excess tissue outside the uterus sheds into the abdomen and surrounding areas, causing inflammation, pain, and the formation of scar tissue.

Before Ovulation: The spike in estrogen that triggers ovulation can stimulate endometrial tissue growth, leading to severe discomfort for those with endometriosis.

Endometriosis Flare-Up Symptoms

During a flare-up, symptoms of endometriosis often worsen. Common physical effects include:

These symptoms can range from mild to debilitating, significantly affecting daily life in some cases.

Learn about the differences between endometriosis and PCOS, the two most common gynecological conditions affecting women of reproductive age.

Managing Endometriosis Flare-Ups

While there is no cure for endometriosis, several management strategies can help reduce the severity and frequency of flare-ups:

Hormonal Treatments:

Aside from pain medications, hormonal treatments are usually the first line of defense for endometriosis. Birth control aims to stop endometrial tissue growth altogether by disrupting the effects of estrogen. Birth control, however, is unfortunately only effective in treating two-thirds of endometriosis patients.

Pain Management:

Surgical Options:

In Conclusion

Endometriosis flare-ups can look different for everyone, so it’s important to recognize which symptoms are unique to you. Guava is a free tool that can help you keep track of your endometriosis symptoms and learn what to expect from each phase of your cycle. If you think you might have endometriosis, don’t hesitate to consult with a doctor before seeking treatment.

Manage Endometriosis with Guava


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